By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
DNTVDNTV
Notification Show More
Aa
  • Home
  • News
    News
    Delaware Newsline endeavors to share stories that challenge dominant narratives, bring context and nuance to complex issues, and support and uplift communities in need.
    Show More
    Top News
    1
    Gallery: Were you seen at the 2018 Delaware Mud Run?
    08/16/2021
    Murder is the second leading cause of death among American teenagers
    06/23/2022
    More than 32,000 Delawareans May Be Eligible for Stimulus Payments
    10/05/2022
    Latest News
    In spite of not having a newspaper photographer, the William Penn HS Graduation Ceremony Still Went On
    06/07/2023
    Delaware Bans Trail Cameras for Recreational Use
    06/01/2023
    Check out The Newly Refurbished Haynes Park In Wilmington
    06/05/2023
    Leaders, NFL Legends to Launch New Child Identification Program in Delaware
    05/26/2023
  • Health
    HealthShow More
    Delaware Officials Provide Latest Updates, Underscore Urgency Surrounding Youth, Opioids, and Prevention Programs 
    06/01/2023
    What You need To Know About COVID-19 Treatment Options
    03/17/2023
    Stray cat in Newark tested positive for rabies, here’s what you need to know
    05/01/2021
    Division of Public Health closes it’s Bureau of Oral Health and Dental Services
    04/15/2021
    ChristianaCare named one of America’s 50 Best Hospitals in The U.S.
    02/10/2021
  • Politics
    Politics
    Delaware Newsline is a digital Delaware News Organization that provides local and national breaking news content to its Delaware and U.S. audience, by utilizing multiple…
    Show More
    Top News
    Watch: Governor Carney’s Easter Message For Delawareans
    10/06/2022
    What you need to know about Delaware’s in-person voting
    10/07/2022
    Delaware high school students are graduating at their highest levels in at least a decade
    10/07/2022
    Latest News
    Senator Tom Carper (D) Will Not Be Seeking Another Term In 2024
    05/22/2023
    Why Governor Carney Did Not Sign HB1, HB2, Legalizing Recreational Marijuana 
    04/24/2023
    Governor Carney Plans to End Public Health Emergency Order in May
    04/07/2023
    Delaware Lt. Governor Bethany Hall-Long Receives National Recognition
    04/06/2023
  • Sports
    Sports
    Delaware Newsline strives to be radically engaged in its communities. You may see us at protests, press releases, community gatherings, and of course at breaking…
    Show More
    Top News
    The investment at Bob Hannah Center is evident now more than ever before
    10/07/2022
    Delaware’s annual State Basketball Tournament takes place Saturday, March 30
    10/07/2022
    76ers Field House set to host first NBA G League Wednesday
    10/07/2022
    Latest News
    Summer Games For Special Olympics Kicks Off Saturday June 9, 2023
    06/04/2023
    DFRC Blue-Gold 2023 Player Rosters Announced
    04/06/2023
    Blue Coats To Host Blue Bombers Tribute
    03/14/2023
    Amid the pandemic, the Blue & Gold All-Star Football Game is cancelled
    10/06/2022
  • Traffic
    TrafficShow More
    Tractor Trailer Fire Shuts Down I-295 NB On The Delaware Memorial Bridge Tuesday Night
    05/31/2023
    Maryland Police Officer Injured After Being Struck Head-On By Drunk Driver
    05/30/2023
    24-Year-Old Man Dies Following Fatal Middletown Crash
    05/26/2023
    Police Investigating Serious Crash On Commons Blvd Thursday Night
    05/25/2023
    Man Charged After Crashing Into Wilmington Police Vehicle That flipped On It’s Side Monday Night
    05/23/2023
  • Weather
  • DNTV
  • Join Us
  • More
Reading: Scientists: Second key pathway in colon cancer stem cell growth
Share
Aa
DNTVDNTV
  • Entertainment
  • Technology
Search
  • Home
  • Categories
    • Technology
    • Entertainment
    • Health
  • Bookmarks
    • Customize Interests
    • My Bookmarks
  • More Foxiz
    • Blog Index
    • Sitemap
Have an existing account? Sign In
Follow US
DNTV > Blog > Health > Scientists: Second key pathway in colon cancer stem cell growth
Health

Scientists: Second key pathway in colon cancer stem cell growth

George Shea
Last updated: 2022/10/07 at 2:39 AM
George Shea Published 10/30/2020 100 Views
Share
5 Min Read
SHARE
- Support Us -
Ad imageAd image

The scientists identified the link between the retinoic acid or RA signaling pathway and another pathway critical to tumor development, called the Wingless-related integration site or WNT pathway. WNT signaling gone wrong is associated with numerous cancers, likely contributing to drug resistance and tumor recurrence.

“There are only a handful of major pathways involved in the regulation of stem cells that control development of the embryo, and we are finding for the first time that dysregulation of two of them, both WNT and RA signaling, are equally important to the development of colorectal cancer,” said Bruce Boman M.D., Ph.D., MSPH, FACP, lead author and senior research scientist at the Cawley Center for Translational Cancer Research at the Graham Cancer Center.

Dr. Boman’s research team has contributed to the understanding of normal stem cells and how cancer stem cells play a role in the development and spread of colorectal cancer.

Tumors develop when mutations or mistakes occur in the normal genes, such as the APC (adenomatous polyposis coli) tumor suppressor gene that regulates stem cell renewal and population size.

“Previously, we discovered that the retinoic acid or RA signaling pathway acts to induce differentiation and maturation of colon stem cells,” Dr. Boman explained.

Building on that work, the investigators found that a distortion in RA signaling caused by APC mutations explains in part why these stem cells remain immature and over-populate.

- Advertisement -
Ad image

The investigators looked at both normal and malignant human colon tissue samples as well as samples from a group of patients with a rare, inherited precancerous condition called familial adenomatous polyposis or FAP.

With help from scientists at the University of Delaware’s Center for Applications of Mathematics in Medicine, the team was able to identify key mechanisms that cause stem cell populations to expand in FAP tissues.

Since APC mutations cause increased WNT signaling in FAP patients and lead to delayed maturation of colonic stem cells, Dr. Boman’s latest research suggests that colorectal cancer evolves from an imbalance between WNT and RA signaling.

“Our new findings draw us even closer to developing more effective stem cell targeting therapies for advanced colorectal cancer,” Dr. Boman said.

Retinoids, derived from vitamin A, are part of the cell communication web along the RA pathway and are used successfully in the treatment of many diseases including skin conditions like acne. Retinoid drugs have also shown promise in treating a variety of cancers, particularly acute promyelocytic leukemia for which retinoid treatment regimens are curative.

“The clues we have uncovered that link both the WNT and RA signaling pathways could potentially spur development of drugs that target cancer stem cells, leading to more effective therapeutics that take this linkage into account,” Dr. Boman added.

Colorectal cancer is the second most deadly cancer worldwide, equally affecting both men and women. Conventional research over the last 50 years has shown that cells undergo a series of genetic mutations that lead to the unchecked growth of tumors and their progression to metastatic cancer. Traditional therapies designed to kill the bulk of cancer tumor cells continue to fall short of a cure for advanced, drug resistant colon cancers.

“Dr. Boman’s findings inch us ever closer to the origins of colorectal cancer at the cellular and molecular level,” said Nicholas J. Petrelli, Bank of America endowed medical director of ChristianaCare’s Helen F. Graham Cancer Center & Research Institute. “His work highlights the mission of the Cawley Center for Translational Cancer Research to hasten discoveries from bench to bedside and draws us even closer on the path to targeted therapies that can improve survival and quality of life for patients with drug resistant, advanced colorectal cancer.”

This research discovery was made possible by generous funding from the Lisa Dean Moseley Foundation for Medical Research on Stem Cells.

- Support Us -
Ad imageAd image

You Might Also Like

Delaware Officials Provide Latest Updates, Underscore Urgency Surrounding Youth, Opioids, and Prevention Programs 

What You need To Know About COVID-19 Treatment Options

Stray cat in Newark tested positive for rabies, here’s what you need to know

Division of Public Health closes it’s Bureau of Oral Health and Dental Services

ChristianaCare named one of America’s 50 Best Hospitals in The U.S.

Subscribe To Web Push Notifications And Get Real Time News Alerts On The Stories That Matter The Most To You!

Stay In Touch! Subscribe To Web Push Notifications And Get Real Time News Alerts On The Stories That Matter The Most To You! Best Of All, You're In Control and can unsubscribe at any time. So What are you waiting for, click the bell icon on the right at the bottom of your browser to get started!
George Shea 10/07/2022 10/30/2020
Share This Article
Facebook Twitter Reddit Email Print
Leave a comment Leave a comment

Leave a Reply Cancel reply

You must be logged in to post a comment.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Happening Now

Breaking
Local
National
Breaking

Breaking

Police Investigating Shooting At Paradise Bar & Grill In Long Neck

Man Shot And Injured During Road Rage Incident Near Old Baltimore Pike
Breaking 06/03/2023
Police Investigating Shots Fired At Large Party Friday Night
Breaking 06/03/2023
Wilmington Man Arrested For Rape Of 12-Year-Old Girl
Breaking 06/02/2023

Local

Local News

In spite of not having a newspaper photographer, the William Penn HS Graduation Ceremony Still Went On

Delaware Bans Trail Cameras for Recreational Use
Local News 06/01/2023
Check out The Newly Refurbished Haynes Park In Wilmington
Local News 06/01/2023
Leaders, NFL Legends to Launch New Child Identification Program in Delaware
Local News 05/25/2023

National

National

Convicted Spy & Former FBI Agent, Robert Hanssen Found Dead In His Cell

Mass Shooting: 2 Killed, 12 others injured at New Jersey House Party
National 05/23/2021
Seven charged in federal court in connection with U.S. Capitol violence
National 01/13/2021
Court blocks Trump effort to exclude undocumented immigrants
National 09/12/2020

- Advertisement -
Ad imageAd image
Environmental
Weather
Traffic
Environmental

Environmental

Burning of Brush, Branches and Limbs Allowed in Delaware Until May 1

Deadly species of hemlock recently found in Sussex County by DNREC
Environmental 07/02/2021
Did you know these students cleanup Deemers Beach in New Castle every Saturday?
Environmental 04/20/2021
One ton of plastic bags will be made into benches by Eco Plastic DNREC says
Environmental 04/15/2021

Weather

BreakingWeather Alerts

Severe Storms On The Way

More Details Released On Saturday’s Tornado Event
Weather & Infrastructure 04/04/2023
Governor Carney Surveys Devastating Tornado Damage In Sussex County
Breaking Weather & Infrastructure 04/02/2023
Watch The moment When A tornado Touched Down in Sussex County
Weather & Infrastructure 04/02/2023

Traffic

Traffic

Tractor Trailer Fire Shuts Down I-295 NB On The Delaware Memorial Bridge Tuesday Night

Maryland Police Officer Injured After Being Struck Head-On By Drunk Driver
Traffic 05/30/2023
24-Year-Old Man Dies Following Fatal Middletown Crash
Traffic 05/26/2023
Police Investigating Serious Crash On Commons Blvd Thursday Night
Traffic 05/25/2023

- Advertisement -
Ad imageAd image
Social Justice
Crime
Courts
Social Justice

Social Justice

Recap of the George Floyd Protest In Wilmington

DOJ Releases Report On Wilmington Police Shooting of Jeremy McDole
Social Justice 09/23/2020
Mayor says community relations is his top priority in upcoming term
Social Justice 09/18/2020
Last Delaware “Whipping Post” to be removed from Georgetown
Social Justice 06/30/2020

Crime

Crime

Police Arrest Man For Swatting Incident That Disrupted Community, Resources, and First Responders

NCCPD, K9 Nova Locates three Suspects During An In-Progress Burglary
Crime 06/02/2023
Update: Arrest Made after Large Fight Erupts At Sussex Central H.S. Graduation Friday
Crime 06/01/2023
Three Teens Linked to Multiple New Castle Robberies
Crime 05/25/2023

Courts

Courts

Ex-Tower Hill employee sentenced for Child Pornography, Sexual Solicitation of a Child

Twenty Charged in Federal and State Court for Drug Conspiracy
Courts 05/28/2023
Lawsuit Filed Against New Castle County After Police Use Deadly Force Killing 22-Year-Old Man
Courts 05/28/2023
Guilty Plea Secured In 2019 Emma Cole Murder By Department Of Justice
Courts 05/25/2023

- Advertisement -
Ad image
Technology
Business
Space
Technology

Technology

Delmarva Power launches “Paint the tank” contest for high school students

Delmarva Power launches “Paint the tank” contest for high school students
Technology 04/18/2018
Two high-tech companies are taking their business to the next level
Technology 03/13/2018
Recreational DRONES and what you need to know about the legal stuff
Technology 11/25/2016

Business

Business

Mayor Purzycki Joins Lounge At Eighth In Ribbon Cutting Ceremony

Capitol One donates it’s $4 million dollar building to Delaware State University
Business 08/08/2021
New model healthcare opens at Wilmington’s Kingswood community center
Business 06/10/2021
Grand Opening At Next Generation Dunkin Donuts in New Castle
Business 04/01/2021

Space

Photo Courtesy Of NASA | Artist's concept of NASA's next-generation Lunar Terrain Vehicle on the surface of the Moon.
Space

If You Have A Lunar Terrain Vehicle, NASA Wants To Hear From You

NASA Mission to Study Ice Clouds, Help Observe Our Dynamic Atmosphere
Space 05/23/2023
NASA Names Astronauts to Next Moon Mission, First Crew Under Artemis
Space 03/30/2023
See Stunning Images of the NASA’s Perseverance Rover Mars Landing
Space 02/19/2021

FOLLOW US

592 Followers Like
349 Followers Follow
21 Followers Follow
66 Subscribers Subscribe
- Advertisement -
Ad imageAd image

More Stories

Most Read
  • From The Producer
  • Environmental
  • Entertainment
  • Community
  • Social Justice
  • Opinions
  • Climate
  • Crime
  • Courts
  • Space
  • Events

About DNTV/Delaware Newsline

Delaware Newsline is a digital Delaware News Organization that provides local and national breaking news content to its Delaware and U.S. audience, by utilizing multiple platforms including web, social media, and video.
Community Support
  • About DNTV/DN
  • Terms & Conditions
  • Report Story Errors
  • Report Infringement
  • Contact An Editor
Support Us Today
  • Submit A Donation
  • Subscription Plans
  • Submit A News Tips
  • Advertise With Us
Follow US
© 2016 Delaware Newsline/DNTV LIVE. All Rights Reserved.
  • Mapping Police Violence
  • Tracking Gun Violence
  • Tracking Cold Cases
  • Coronavirus
Subscribe For The Stories That Matter The Most

Stay In Touch! Get the latest news alerts delivered straight to your email. You can unsubscribe at any time.


Loading
Zero spam, Unsubscribe at any time.
adbanner
AdBlock Detected
Our site is an advertising supported site. Please whitelist to support our site.
Okay, I'll Whitelist

Insert/edit link

Enter the destination URL

Or link to existing content

    No search term specified. Showing recent items. Search or use up and down arrow keys to select an item.